Effect of calcium content of diet on crystal formation in urine of patients with calcium oxalate stones: a randomized crossover clinical trial

Abstract Background Patients with idiopathic calcium oxalate stones are advised to consume a low-oxalate diet prevent recurrence. In this study, on patients we have attempted determine the effect of content formation crystals in urine by vitro supersaturation study fresh postprandial samples and observing morphology formed using polarized optical microscopy. Methods The trial was conducted as prospective interventional randomised crossover clinical repeated measures design. Sixty no metabolic abnormalities treated lithotripsy at tertiary care centre during period May 2016 2019 were recruited. Following 14 h overnight fasting, collected after providing patient either low- or high-calcium meal for breakfast followed four hours later, high-oxalate lunch. Urine tested multiple parameters including pH, specific gravity, calcium/creatinine ratio sodium density measurement spectrophotometry microscopic analysis formed. Results Optical values obtained significantly higher than corresponding sample low-calcium ( p < 0.001). These findings reflected their size, shape number. When urinary levels low, following diet. Conclusions High contributes kidney stone formation. There is lower risk even consumption